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IBL/Haemophilus influenzae B (HIB) IgG ELISA/RE56351/

IBL/Haemophilus influenzae B (HIB) IgG ELISA/RE56351/
  • IBL/Haemophilus influenzae B (HIB) IgG ELISA/RE56351/
商品介绍
Kitsize12x8
MethodELISA
Incubationtime2x1h,1x30min
StandardrangeLotspecific
Specimen/Volumes20µlSerum,Plasma
Substrate/isotopeTMB450nm
RegulatoryStatus:EU:CE,CDN:IVD
Detailsfor: HaemophilusinfluenzaeB(HIB)IgGELISA
HaemophilusinfluenzaetypeB(HiB)isaverycommoncauseofinvasivecriticalinfectiousdiseasesinchildrenuptotheageofsix.Followinginfectionthesymptomsofthediseaseinclude:Pericarditis,osteomyelitis,meningitis,encephalitis,pneumonia,sinusitisandotitis.Inmanycasesthediseaseislethalorleadstoneurologicaldamage,whichcannotalwaysbepreventedbyrapidantibiotictherapy.Theunderlyingreasonforthediseaseisveryoftenalatentimmunodeficiencywithaspecificallyreducedhumoralimmuneresponsetothepolyribosylribitolphosphate(PRP)inthepolysaccharideencapsulationofthebacterium.Inchildrenanotherreasonistheimmaturityoftheimmunesystem.Todayoftentheterm"immunocompromisedpatients"isused,comprisingallacquiredandinnatespecificandunspecificimmunodeficiencies.
Asaresult,inchildrenof3monthsofageorolderavaccinationwithdifferentsortsofPRP-containingvaccinesisrecommended.ThiscanleadtoaclearreductioninthenumberofinfectionswithHaemophilusinfluenzaetypeB.
Thetiterofantibodiesproducedbyvaccinationcanbeusedtoconfirmwhetherthevaccinationhasbeensuccessful.TheHiBIgGisusedtomeasurethelevelofPRP-specificIgG-antibodiesfollowinga46weekperiodaftercompleteimmunizationtomonitorthehumoralimmunestatusofchildrenorotherindividualsatrisk.
Monitoringofthehumoralimmunostatusaftervaccination.VerificationofthediagnosisHaemophilusinfluenzaetypeBinfectionbyrepeatedmonitoringofantibodyconcentrations.RiskassessmentinimmunocompromisedpatientsleADIngtoafailureofvaccinationwithaPRP-containingvaccine.
Thisgroupcomprises:
Childrenunder2yearshavinghadaninfectionwithHaemophilusinfluenzaetypeB,
Childrenwithchronic,recurringbacterialinfectionsoftherespiratorytract,
Childrenwithchronicotitis,
Patientswithconfirmedhumoralimmuno-deficiencies(IgG-2-deficiency,IgA-deficiency),
Patientswithconfirmedgranulocytedeficiencies,
Patientsunderchemoorcytostatictherapy,
Childrenaftersplenectomy,
Patientswithsickle-cellanaemia,
Patientswithtrisomy21(Down)syndrome,andcertainethnicgroups.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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